Research Papers-Peer Reviewed:
1. Kornblum, HI, and Johnson, EM Jr. (1982) Time and dose dependencies of effects of nerve growth factor on sympathetic and sensory neurons in neonatal rats. Brain Res, Vol. 234, 41-51.
2. Loughlin, SE, Massimiri, TR, Kornblum, HI, and Leslie, FM (1985) Postnatal development of opioid systems in rat brain. Neuropeptides, Vol. 5, 469-472.
3. Kornblum, HI, Loughlin, SE, and Leslie, FM (1987) Effects of morphine on DNA synthesis in neonatal rat brain. Dev. Brain Res, Vol. 31, 45-52.
4. Morrison, RS, Kornblum, HI, Leslie, FM, and Bradshaw, RA (1987) Trophic stimulation of cultured central nervous system neurons by epidermal growth factor. Science, Vol. 238, 72-75.
5. Kornblum, HI, Hurlbut, DE, and Leslie, FM (1987) Postnatal Development of multiple opioid receptors in rat brain. Dev. Brain Res, Vol. 37, 21-41.
6. Kornblum, HI, Raymon, HK, Morrison, RS, Cavanaugh, KP, Bradshaw, RA, and Leslie, FM (1990) Epidermal growth factor and basic fibroblast growth factor: effects on an overlapping population of neocortical neurons in vitro. Brain Res, Vol. 535, 255-263.
7. Kornblum, HI, Corwin, JT, and Trevarrow, B, (1990) Selective labeling of sensory hair cells and neurons in auditory, vestibular, and lateral line systems by a monoclonal antibody. J Comp Neurol, Vol. 301, 162-70.
8. Loughlin, SE, Kornblum, HI, Massamiri, T, and Leslie, FM (1991) Transient appearance of b-endorphin immunoreactive cells within the germinal zone of neonatal rat forebrain. Int. J. Dev. Neurosci, Vol. 9, 493-500.
9. Kornblum, HI, Chugani, HT, Tatsukawa, K, and Gall, CM (1994) Cerebral hemispherectomy alters expression of transforming growth factor mRNA in developing rat brain. Mol. Brain Res, Vol. 21, 107-114.
10. Seroogy, KB, Numan, S., Gall, C.M., Lee, D.C., Kornblum, HI, (1994) Expression of EGF receptor mRNA in rat nigrostriatal system. Neuroreport, Vol. 6, 105-108.
11. Seroogy, KB, Gall, CM, Lee, DC, and Kornblum, HI, (1995) Proliferative zones of developing rat brain express epidermal growth factor receptor mRNA. Brain Res, Vol. 670, 157-164.
12. Kornblum, HI, Gall, CM, Seroogy, KB, and Lauterborn, JC (1995) A subpopulation of striatal GABAergic neurons expresses the epidermal growth factor receptor. Neuroscience, Vol. 69, 1025-1029.
13. Shih, JJ, Kornblum, HI, and Shewmon, DA (1996) Global brain dysfunction in an infant with pyridoxine dependency: evaluation with EEG, evoked potentials, MRI, and PET. Neurology, Vol. 47, 824-826.
14. Kornblum, HI, Sankar, R, Shin, D, Wasterlain, C, and Gall, CM, (1997) Induction of brain derived neurotrophic factor mRNA by seizures in neonatal and juvenile rat brain. Mol Brain Res, Vol. 44, 219-228.
15. Kornblum, HI, Hussain, R, Tatsukawa, KT, Bronstein, J, Lee, D, Gall, CM, and Seroogy, KB (1997) Prenatal ontogeny of epidermal growth factor receptor and transforming growth factor alpha mRNAs in rat brain. J. Comp. Neurol, Vol. 380, 243-261.
16. Mathern, GW, Pretorius, JK, Kornblum, HI, Mendoza, D, Lozada, A, Leite, JP, and Leila, MC (1997) Human hippocampal AMPA and NMDA mRNA levels in temporal lobe epilepsy, Brain, Vol. 120, 1937-1959.
17. Umbach, JA, Grasso, A, Zurcher, SD, Kornblum, HI, Mastrogiacomo, A, and Gundeersen, CB (1998) Electrical and optical monitoring of latrotoxin action at Drosophila neuromuscular junctions, Neuroscience Vol. 87, 913-924.
18. Mastrogiacomo, A., Kornblum, HI, Umbach, JA, and Gundersen, CB (1998) A Xenopus cysteine string protein with a cysteine residue in the J domain. Biochem. Piophys. Acta, Vol. 1401, 239-241.
19. Kornblum, HI, Hussain, R, Wiesen, J, Miettinen, P, Zurcher, SD, Chow, K, Derynck, R, and Werb, Z (1998) Abnormal astrocyte development and neuronal death in mice lacking the epidermal growth factor receptor. J. Neurosci. Res. 53: 697-717.
20. Mathern, GW, Pretorius, JK Leite, JP, Kornblum, HI, Mendoza, D, Lozada, A, and Bertram, EH (1998) Hippocampal AMPA and NMDA mRNA levels and subunit immunoreactivity in human temporal lobe epilepsy patients and a rodent model of chronic mesial limbic epilepsy. Epilepsy Res. 32:154-171.
21. Mathern GW, Pretorius JK, Kornblum HI, Mendoza D, Lozada A, Leite JP, Chimelli L, Born DE, Fried I, Sakamoto AC, Assirati JA, Peacock WJ, Ojemann GA, and Adelson, PD. (1998) Altered hippocampal kainate-receptor mRNA levels in temporal lobe epilepsy patients. Neurobiology of Disease, Vol 5, 151-176.
22. Mathern, GW, Pretorius JK, Mendoza D, Lozada A, and Kornblum HI. (1998) Hippocampal AMPA and NMDA mRNA levels correlate with aberrant fascia dentata mossy fiber sprouting in the pilocarpine model of spontaneous limbic epilepsy. Journal of Neurosci. Res. Vol 54, 734-753.
23. Mathern, GW, Pretorius JK, Mendoza D, Leite JP, Chimelli L, Born DE, Fried I, Assirati JA, Ojemann GA, Adelson PD, Cahan LD, and Kornblum HI. (1999) Hippocampal NMDA receptor subunit mRNA levels in temporal lobe epilepsy patients. Annals of Neurology, Vol 46, 343-358..
24. Kornblum, HI, Zurcher, S, Werb, Z, Derynck, R and Seroogy, KB, (1999) Multiple trophic actions of Heparin-binding epidermal growth factor in the brain, European Journal of Neuroscience, Vol 11, 3236-3246.
25. Kornblum, HI, Yanni, DS, Easterday, MC and Seroogy, KB (2000) Expression of the EGF Receptor Family Members ErbB2, ErbB3, and ErbB4 in Germinal Zones of the Developing Brain and in Neurosphere Cultures Containing CNS Stem Cells. Dev. Neursoci., Vol. 22, 16-24 (invited submission for special issue on CNS stem cells.)
26. Bronstein, J.M, Chen, K., Tiwari-Woodruff, S, and Kornblum, HI (2000) Developmental expression of OSP/Claudin -11 in. J. Neurosci. Res., Vol 60, 284-290.
27. Liau, L, Buznikov, A, Lallone, R, Seitz, R, Gregg, J, Kornblum, HI, Nelson, S, and Bronstein, JM (2000) Identification of a glioblastoma-associated growth factor gene, granulin, using differential immuno-absorption, Cancer Res, Vol. 60, 1353-60.
28. Kornblum, HI, Araujo, DM, Annala, AJ, Tatsukawa, K, Phelps, ME and Cherry, SR (2000) In vivo imaging of neuronal activation and plasticity in the rat brain by high resolution positron emission tomography (microPET) Nature Biotech.,Vol. 18, 655-660.
29. Araujo, DM, Cherry, S Tatsukawa, K, Toyokuni, T, and Kornblum, HI (2000) Deficits in striatal dopamine d2 receptors and energy metabolism detected by in vivo microPET imaging in a rat model of Huntington's disease, Experimental Neurology, Vol. 166, 287-297.
30. Kinoshita, Y, Jarell, AD, Flaman, JM, Foltz, G, Sopher, BL, Kanning, K, Irvin, DK, Kornblum, HI, Nelson, P, Hieter, P and Morrison, RS (2001) Characterization of Pescadillo, a novel cell cycle regulatory protein abnormally expressed in malignant astrocytes, J. Biol. Chem., Vol. 276, 6656-65..
31. Gundersen, CB, Aguado, F, Sou, S, Mastrogiacomo, A, Coppola, T, Kornblum, HI, and Umbach, JA (2001) Cysteine string proteins are associated with cortical granules of Xenopus laevis oocytes, Cell and Tiss. Res., Vol 303, 211-219.
32. Geschwind, DH, Ou, J, Easterday, M, Terskikh, A, Weissman, I, Chen, Z, Nelson, S and Kornblum, HI (2001) A genetic analysis of neural progenitor differentiation, Neuron, Vol. 29, 325-339.
33. Terskikh, A, Easterday, MC, Li, L, Hood, L, Kornblum, HI, Geschwind, DH and Weissman, IL (2001) From Hematopoiesis to Neuropoiesis: Evidence of overlapping genetic programs, PNAS, Vol. 98, 7934-7939. PMID: 11438922 PMCID: 35446.
34. Irvin, DK, Zurcher, SD, Nguyen, T, Weinmaster, G and Kornblum, HI (2001) Expression patterns of Notch1, Notch2 and Notch3 suggest multiple functional roles for the Notch-DSL signaling system during brain development, J. Comp. Neurol., Vol. 436, 167-181.
35. Tiwari-Woodruff, SK, Buznikov, AG, Vu, T, Micevych, PE, Kornblum, HI and Bronstein, JM (2001) OSP/claudin-11 forms a complex with a novel member of the tetraspanin super family and B-1 integrin and regulates proliferation and migration of oligodendrocytes, J. Cell Biol., Vol. 153 295-305. PMID: 11309411 PMCID: 2169454.
36. Ott, D A., Caplan, R, Guthrie,D, Prahba S, Komo, S, Shields, D, Sankar, R, Kornblum, H, Chayasirisobhon, S (2001) Severe Psychopathology in Children with CPS and PGE, Journal of the Amercian Academy of Child and Adolescent Pscychiatry Vol. 40, 907-914.
37. Caplan, R. Guthrie, D.Komo, S.Shields, W.D., Chayasirisobhon, S, Kornblum, H.I., Mitchell, W., and Hanson, R. (2001) Conversational repair in pediatric epilepsy. Brain Lang, Vol. 78, 82-93.
38. Groszer, M, Erickson, R, Lesche, R, Trumpp, A, Kornblum, HI, Liu, X, Wu, H, (2001) Negative Regulation of Neural stem/progenitor Cell Proliferation by the Pten Tumor Suppressor Gene in Vivo, Science, Vol. 294, 2186-2189.PMC1325011
39. Bruce, LL, Kornblum, HI, Seroogy, KB (2002) Comparison of thalamic populations in mammals and birds: ErbB4 mRNA expression, Brain Res Bull , 455-461
40. Dhaka, A, Costa, RM, Irvin, DK, Patel, A, Hu, H, Kornblum, HI, Silva, AJ, O’Dell, TJ, and Colicelli, J (2003) Deletion of the Ras Effector Rin1 Enhances Long Term Memory, J. Neurosci., Vol. 23, 748-757.
41. Imura, T, Kornblum, HI, and Sofroniew, MV(2003) The Predominant Neural Stem Cell Isolated from Postnatal and Adult, but not Early Embryonic, Forebrain Expresses GFAP, J. Neurosci. Vol. 23, 2824-2832.
42. Fu, L, Abu-Khalil, A, Morrison, RS, Geschwind, DH and Kornblum, HI (2003) The expression patterns of epidermal growth factor receptor and fibroblast growth factor receptor 1 mRNA in fetal human brain, J. Comp. Neurol.,Vol. 462, 265-273.
43. Irvin, DK, Dhaka, A, Hicks, C, Weinmaster, G and Kornblum, HI (2003), Extrinsic and intrinsic factors governing cell fate in cortical progenitor cultures, Dev. Neursoci., Vol. 25, 162-172 (Invited submission for special issue).
44. Karsten, S, Kudo, L, Jackson, R, Sabatti, C, Kornblum, HI and Geschwind, DH (2003) Identifiying cell cycle and regulatory network in differentiating mouse neural progenitors, Dev. Biol., Vol. 261, 165-182.
45. Easterday, MC, Dougherty, JD, Nakano, I, Jackson, RL, Paucar, AA, Ou, J, Roobini, B, Dianati, M, Irvin, DK, Terskikh, A, Weissman, IL, Geschwind, DH, and Kornblum, HI (2003) Neural Progenitor Genes: Germinal zone expression and analysis of genetic overlap in stem cell populations. Dev. Biol., Vol. 264, 309-322.
46. Hemmati, HD, Nakano, I, Lazareff, JA, Masterman-Smith, M, Geschwind, DH, Bronner-Fraser, M and Kornblum, HI (2003) Cancerous stem cells can arise from pediatric brain tumors, PNAS, Vol. 100, 15178-15183. PMC299944
47. Irvin, DK, Nakano, I, Paucar, A and Kornblum, HI (2004) Paterns of Jagged 1, Jagged 2, Delta-like 1 and Delta-like 3 expression during late embryinic and postnatal brain develoment suggest multiple funcitonal roles in progenitors and differentiated cells, J Neurosci Res., Vol. 75, 330-43.
48. Mir, H, Tatsukawa, KT, Carmichael, ST, Chesselet, MF and Kornblum, HI (2004) Metabolic correlates of lesion-specific plasticity: an in vivo imaging study, Brain Res., Vol. 1002, 28-34.
49. Carmichael, ST, Tatsukawa, KT, Katzman, D, Tsuyuguchi, N, and Kornblum, HI (2004) Evolution of disachisis in a focal stroke model. Stroke, Vol.. 35, 758-63.
50. Tiwari-Woodruff, S, Kaplan, R, Kornblum, HI, and Bronstein, JM (2004) Developmental Expression of OAP-1/Tspan-3, a Member of the Tetraspanin Super Family, J. Neurosci. Res., Vol. 77, 166-73.
51. Fox, IJ, Paucar, AA, Nakano, I, Mottahedeh, J, Dougherty, JD, and Kornblum, HI (2004), Developmental Expression of glial fibrillary acidic protein (GFAP) mRNA in mouse forebrain germinal zones—implications for stem cell biology, Dev. Brain Res.Vol. 153, 121-125.
52. Fox, IJ, and Kornblum, HI (2004) Developmental expression of ErbB receptors in murine central nervous system—implications for functional interactions, J. Neurosci Res. Vol. 79, 584-97.
53. Nakano, I., *Paucar, A.A., *Bajpai, R., *Dougherty, J,.D., Zewail, A., Kelly, T.K., Kim, K.J., Ou, J., Groszer, M., Imura, T., Freije W.A., Nelson, S.F., Sofroniew, M.V., Wu, H., Liu, X., Terskikh, A.V., Geschwind, D.H., and Kornblum, H.I., (2005) Maternal Embryonic Leucine Zipper Kinase (MELK) Regulates Multipotent Neural Progenitor Proliferation, J. Cell Biol., Vol. 170, 413-427. PMC2171475
54. Imura, T., Nakano, I., Kornblum,H.I., and Sofroniew, M.V., (2006) Phenotypic and functional heterogeneity of GFAP-expressing cells in vitro: Differential expression of LeX/CD15 by GFAP-expressing multipotent neural stem cells and non-neurogenic astrocytes. Glia Vol. 53, 277-293 .
55. Dougherty, J.D, Garcia, A.D.R., Nakano, I., Livingstone, M. Norris, B, Polakiewicz, R. D., Sofroniew, M.V., Kornblum H.I. , and Geschwind, D.H. (2005) PBK/TOPK, a proliferating progenitor specific MAPKK, J. Neurosci., Vol. 25, 10773-85.
56. Visnyei, K., Tatsukawa, K.M., Erickson, R.I., Simonian, S., Oknaian, N., Carmichael, S.T., and Kornblum, H.I.(2005) ;Neural progenitor implantation restores metabolic deficits in the brain following striatal quinolinic acid lesion, Exp. Neurol., 197(2):465-7
57. Groszer, M, Erickson, R, Scripture-Adams, D.D, Dougherty, JD, Labelle, J, Zack, JA, Geschwind, DH, Liu, X, Kornblum, H.I.*, and Wu, H* (2006) PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry, PNAS, Vol. 103, 111016. *Co-corresponding author. PMC2206628
58. Horvath S, Zhang B, Carlson M, Lu KV, Zhu S, Felciano RM, Laurance MF, Freije W, Qi, S, Lee Y, Scheck AC, Liau LM, Wu H, Geschwind DH, Febbo PG, Kornblum HI, Cloughesy TF, Nelson SF* Mischel PS*(2006). Analysis of Oncogenic Signaling Networks in Glioblastoma Identifies ASPM as a Novel Molecular Target, PNAS, 103(46):17402-7.PMID: 17090670 PMCID: 1635024.
59. Nakano, I, Dougherty, JD, Kim, K, Klement, I, Geschwind, DH, and Kornblum, HI, (2007) Phosphoserine phosphatase is expressed in the neural stem cell niche and regulates neural stem and progenitor cell proliferation, Stem Cells, 25(8):1975-84.
60. Nakano, I, Masterman-Smith, M, Saigusa, K, Paucar, AA, Horvath, S, Shoemaker, L, Watanabe, M, Negro, A, Bajpai, R, Howes, A, Lelievre, V, Waschek, JA, Lazareff, JA, Freije, WA, Liau, LM, Gilbertson, RJ, Cloughesy, TF, Geschwind, DH, Nelson, SF, Mischel, PS, Terskikh, AV, and Kornblum, HI (2008) Maternal Embryonic Leucine Zipper Kinase (MELK) is a key regulator of the proliferation of malignant brain tumors, including brain tumor stem cells, J. Neurosci. Res., Aug 24;86(1):48-60
61. Saxe JP, Wu H, Kelly TK, Phelps ME, Sun YE*, Kornblum HI*, Huang J*+ (2007). A phenotypic small molecule screen identifies an orphan ligand-receptor pair that regulates neural stem cell differentiation. Chem. Biol. (now Cell Chemical Biology) 2007. 14(9): 1019. PMID 17884634 PMCID: 2758915 * Co- corresponding author. + Cover article.
62. Liu T, Papagiannakopoulos T, Puskar K, Qi S, Santiago F, Clay W, Lao K, Lee Y, Nelson SF, Kornblum HI, Doyle F, Petzold L, Shraiman B, Kosik KS (2007). Detection of a microRNA signal in an in vivo expression set of mRNAs. PLoS ONE. 2007 Aug 29;2(8):e804 PMID: 17726543 PMCID: 1950084.
63. Lelievre,V Seksenyan, A, Nobuta, H, Yong, W, Chhith, S Seririthanar, Niewiadomski, P, Cohen, J, Dong, H, Flores, A, Liau, L, Kornblum HI, Scot, P, Waschek, J (2008) Disruption of the PACAP gene promotes medulloblastoma in PTC1 Mutant Mice, Dev Biol. 2008 Jan 1;313(1):359-70 PMID: 18036580 PMCID: 2206628.
64. Erickson, RE, Visnyei, A, Paucar, AA and Kornblum, HI (2007) The Roles of Insulin and Transferrin in Neual Progenitor Survival and Proliferation in vitro, J. Neurosci. Res., 86: 1884-94.
65. Kelly TK, Karsten SL, Geschwind DH and Kornblum HI (2009) Cell lineage and regional identity of cultured spinal cord neural stem cells and comparison to brain-derived neural stem cells, PlosOne, 4(1):e4213. Epub 2009 Jan 16.PMID: 19148290 PMCID: 2615219.
66. Karumbayaram S, Kelly TK, Paucar AA, Roe AJ, Umbach JA, Charles A, Goldma SA, Kornblum HI*, and Wiedau-Pazos M* (2009) Human embryonic stem cell-derived motor neurons expressing SOD-1 mutants exhibit typical signs of motor neuron degeneration linked to ALS, Disease Models and Mechanisms, 2(3-4):189-95. PMID 19259395 PMCID: 2650191 * Co- corresponding authors.
67. Gregorian C, Nakashima J, Le Belle J, Ohab J, Kim R, Liu A, Barzan-Smith K, Groszer M, Garcia AD, Sofroniew MV, Carmichael ST, Kornblum HI, Liu X, Wu H (2009) Pten deletion in adult neral stem/progenitor cells enhances constitutive neuogenesis, J. Neurosci, 29(6):1874-86. PMID: 19211894 PMCID: 2754186.
68. Laks DR, Masterman-Smith MM, Visnyei K, Angenieux B, Orozco NM, Foran I, Yong WH, Vinters HV, Liau LM, Lazareff JA, Mischel PS, Cloughesy TF, Horvath S, Kornblum HI (2009) Neurosphere formation is an independent predictor of clinical outcome in malignant glioma. Stem Cells, 27(4):980-987. PMID: 19353526.PMC3177534
69. Wexler, EM, Paucar A, Kornblum HI, Palmer TD, Geschwind DH (2009) Endogenous Wnt signaling maintains neural progenitor cell potency, Stem Cells. 2009 May;27(5):1130-41.PMID: 19418460 PMCID: 2782960
70. Karumbayaram S, Novitch BG, Umbach JA, Richter L, Lindgren A, Conway A, Clark A, Goldman SA, Plath K, Wiedau-Pazos M*, Kornblum HI*, Lowry WE* (2009) Directed differentiation of human induced-pluripotent stem cells (iPS) generates active motor neurons, Stem Cells, 27(4):806-811. PMID: 19350680. * Co-Corresponding authors.
71. Lewerenz J, Albrecht P, Tien ML, Henke N, Karumbayaram S, Kornblum HI, Wiedau-Pazos M, Schubert D, Maher P, Methner A. (2009) Induction of Nrf2 and xCT are involved in the action of the neuroprotective antibiotic ceftriaxone in vitro. J Neurochem. 111 (2): 332-43. PMID: 19694903 PMC: 2817745.
72. Shoemaker LD , Orozco NM, Geschwind DH, Whitelegge JP, Faull KF, Kornblum HI (2010) Identification of differentially expressed proteins in murine embryonic and postnatal cortical neural progenitors, PLoS ONE, eb 9;5(2):e9121. PMID: 20161753 PMCID: 2817745
73. Zhong JI, Chan A, Morad L, Kornblum HI, Fan G, Carmichael ST (2010) Hydrogel Matrix to Support Stem Cell Survival after Brain Transplantation in Stroke. Neurorehabilitation and Neural Repair. Sep;24(7):636-44.PMID: 20424193. PMC4697440
74. Panosyan EH, Laks DR Masterman-Smith M, Mottahedeh J, Yong WH, Cloughesy TF, Lazareff JA, Mischel PS, Moore TB, Kornblum HI (2010) Clinical Outcome in Pediatric Glial and Embryonal Brain Tumors Correlates with In Vitro Multi-passageable Neurosphere Formation, Pediatric Blood and Cancer, Oct;55(4):644-51.
75. Sun J, Masterman-Smith M, Graham NA, Jiao J, Mottahedeh J, Laks DR, Ohashi M, DeJesus J, Kamei K, Lee K, Wang H, Yu ZTF, Lu YT, Hou S, Li K, Liu M, Zhang N, Want S, Angenieux B, Panosyan E, Samuels ER, Park J, Williams D, Konkankit V, Nathansaon D, van Dam RM, Phelps ME, Wu H, Liau LM, Mischel PS, Lazareff JA, Kornblum HI*, Yong WH*, Graeber TG*, Tseng HR* (2010), A microfluidic platform for systems pathology: multiparameter single-cell signaling measurements of clinical brain tumor specimens, Cancer Research, 2010 Aug 1;70(15):6128-38. *Co-corresponding author. PMC3163840
76. Le Belle JE, Orozco NM, Paucar AA, Saxe JP, Mottahedeh J, Pyle AD, Wu H, Kornblum HI (2011) Proliferative Neural Stem Cells Have High Endogenous ROS Levels that Regulate Self-Renewal and Neurogenesis in a PI3K/Akt-Dependant Manner, Cell Stem Cell, Jan 7;8(1):59-71.PMC3018289
77. Neveu P, Kye MJ, Qi, S, Sahin, M, Park IH, Kim KS, Daley GQ, Kornblum HI, Shraiman BI, Kosik KS (2011) MicroRNA profiling reveals two distinct p53-related human pluripotent stem cell states, Cell Stem Cell, Dec 3;7(6):671-81.
78. Nakano I, Joshi K, Visnyei K, Watanabe M, Wexler E, Saigusa K, Nakamura Y, Laks DR, Mischel PS, Viapiano, Kornblum HI (2011) Siomycin A targets brain tumor stem cells partially through a MELK-mediated pathway, Neuro-Oncology, 13(6):622-34. PMC3107094
79. Jijiwa M, Demir H, Gupta S, Leung C, Joshi K, Orozco N, Huang T, Yildiz VO, Shibahara I, de Jesus JA, Yong WH, Mischel PS, Fernandez S, Kornblum HI and Nakano I (2011) CD44v6 regulates brain tumor stem cell growth partially through the AKT-mediated pathway, PLoSOne;6(9):e24217 PMC3167830
80. Visnyei K, Onodera H, Damoiseaux R, Saigusa K, Petrosyan1 S, De Vries D, Ferrari D, Saxe Jo, Panosyan E, Masterman-Smith M, Mottahedeh J,. Bradley K A, Huang J, Sabatti C, Nakano I, and Kornblum HI (2011) A molecular screening approach to identify and characterize inhibitors of glioblastoma multiforme stem cells, Molecular Cancer Therapeutics, Oct 10; 10, 1818-28. PMC3191241
81. Liu Y, Ye F, Yamada K , Tso J, Zang Y, Nguyen DH, Dong Q , Soto H , Choe J , Dembo J , Wheeler H , Eskin A , Schmid I , Yong WH, Mischel PS , Cloughesy TF , Kornblum HI , Nelson SF, Liau LM, Tso CL (2011) Autocrine endothelin-3/endothelin receptor B signaling maintains cellular and molecular properties of tumorigenic glioblastoma stem cells, Molecular Cancer Research, Dec;9(12):1668-85.
82. Pope WB, Prins RM, Thomas MA, Nagarajan R, Yen KE, Bittinger MA, Salamon N, Chou AP, Yong WH, Soto H, Wilson N, Driggers E, Jang HG, Su SM, Schenkein DP, Lai A, Cloughesy TF, Kornblum HI, Wu H, Fantin VR, Liau LM (2012) Non-invasive detection of 2-hydroxyglutarate and other metabolites in IDH1 mutant glioma patients using magnetic resonance spectroscopy, Journal of J Neurooncol, Mar;107(1):197-205. PMC3650613
83. Chou AP, Chowdhury R, Li S, Chen W, Kim AJ, Piccioni DE, Selfridge JM, Mody RR, Chang S, Lalezari S, Lin J, Sanchez DE, Wilson RW, Garrett MC, Harry B, Mottahedeh J, Nghiemphu PL, Kornblum HI, Mischel PS, Robert M. Prins RM, Yong,WH, Cloughesy T, Nelson SF, Linda M. Liau LM, Lai A (2012) Identification of Retinol Binding Protein 1 Promoter Hypermethylation in Isocitrate Dehydrogenase 1 and 2 Mutant Gliomas, J Natl Cancer Inst. 2012 Oct 3;104(19):1458-6. PMC3529615.
84. Joshi K, Banasavadi-Siddegowda Y, Mo X, Kim S, Mao P, Kig C, Nardini D, Sobol RW, Chow L, Kornblum HI, Waclaw R, Beullens M, and Nakano I (2013) MELK-dependent FOXM1 phosphorylation is essential for proliferation of glioma stem cells. Stem Cells Jun;31(6):1051-63 PMC3744761
85. Akhavan D, Pourzia AL, Nourian AA, Williams KJ, Nathanson D, Babic I, Villa GR, Tanaka K, Nael A, Yang H, Dang J, Vinters HV, Yong WH, Flagg M, Tamanoi F, Sasayama T, James CD, Kornblum HI, Cloughesy TF, Cavenee WK, Bensinger SJ, Mischel PS (2013) De-Repression of PDGFRβ transcription Promotes Acquired Resistance to EGFR Tyrosine Kinase Inhibitors in Glioblastoma Patients, Cancer Discovery, May;3(5):534-547.
86. Nathanson DA, Gini B, Mottahedeh J, Visnyei K, Koga T, Gomez G, Eskin A, Hwang K, Wang J, Masui K, Paucar A, Yang H, Ohashi M, Zhu S, Wykosky J, Reed R, Nelson S, Cloughesy TF, James CD, Rao PN, Kornblum HI*, Heath JR*, Cavenee WK*, Furnari FB*, Mischel PM* (2014) Targeted therapy resistance mediated by dynamic regulation of extrachromosomal mutant EGFR DNA, Science, 343(6166):72-6 PMID:24310612 * Denotes Co-Senior Authors with equal contributions.
87. Lee H, Lin MA, Kornblum HI, Papazian DM, Nelson SF (2014) Exome sequencing identifies de novo gain of function missense mutation in KCND2 in identical twins with autism and seizures that slows potassium channel inactivation, Hum Mol Gen, Feb 18. [Epub ahead of print] PMID: 24501278
88. Panosyan EH, Wang Y , Xia P , Lee W, Pak , Y, Laks DR, Lin HJ, Moore TB , Cloughesy TF , Kornblum HI , Lasky JL (2014) Asparagine Depletion Potentiates the Cytotoxic Effect of Chemotherapy Against Brain Tumors, Mol. Cancer Res., 12(5):694-702. PMID:24505127
89. Minata M, Gu C, Joshi K, Nakano-Okuno M, Hong C, Nguyen CH, Kornblum HI, Molla A, Nakano (2014) Multi-kinase inhibitor C1 triggers mitotic catastrophe of glioma stem cells mainly through MELK kinase inhibition, PLoSOne, Apr 16;9(4):e92546. doi: 10.1371/journal.pone.0092546 PMC3989164
90. Thomsen GM, Le Belle JE, Harnisch, JA, Mc Donald W, Hovda DA, Sofroniew MV, Kornblum HI*, Harris NG* (2014) Traumatic brain injury reveals novel cell lineage relationships within the subventricular zone, Stem Cell Research, 13(1): 48-60. *Co-Senior, corresponding authors.
91. Le Belle JE, Sperry J, Ngo A, Laks DR, Kornblum HI (2014) Maternal inflammation contributes to brain overgrowth and autism-associated behavioral abnormalities through altered redox signaling in stem and progenitor cells. Stem Cell Reports, Nov 11;3(5):725-34. PMC4235743
92. Fabritius AL, Vesa J, Minye HM, Nakano I, Kornblum H, Peltonen L (2014) Neuronal ceroid lipofuscinosis genes, CLN2, CLN3 and CLN5 are spatially and temporally co-expressed in a developing mouse brain. Exp Mol Pathol. 2014 Dec;97(3):484-91.
93. Laks DR, Ta L, Gao F, Crisman T, Coppola G, Radu CG, Nathanson DA, Kornblum HI (2016). Inhibition of Nucleotide Synthesis Targets Brain Tumor Stem Cells in a Subset of Glioblastoma. Molecular Cancer Therapeutics, 2016 Jun;15(6):1271- PMID: 27196770.
94. Laks, DR, Crisman, TJ, Shih MYS, Mottahedeh J, Gao F, Sperry J, Garrett MC, Yong WH, Cloughesy TF, Liau LM, Lai A, Coppola G, Kornblum HI, (2016) Large-scale Assessment of the Gliomasphere Model System, Neuro-Oncology, Oct;18(10):1367-78. PMID: 27116978
95. Crisman TJ, Zelaya I, Laks DR, Zhao Y, Kawaguchi R, Gao F, Kornblum HI, Coppola G. (2016) Identification of an Efficient Gene Expression Panel for Glioblastoma Classification. PLoSOne, Nov 17;11(11):e0164649. PMID:27855170
96. Turner KM, Deshpande V, Beyter D, Koga T, Rusert J, Lee C, Li B, Arden K, Ren B, Nathanson DA, Kornblum HI, Taylor MD, Kaushai S, Cavanee WK, Wechsler-Reya R, Furnari FB, Vandenberg SR, Rao PN, Bafna V, Mischel PS (2017) Extrachromosomal oncogene amplification drives tumor evolution and genetic heterogeneity, Nature, Mar 2;543(7643):122-125 PMID: 28178237. PMC5334176
97. Le T, Poddar S, Capri J, Abt E, Kim W, Wei L, Uong N, Cheng C, Brass D, Nikanjam M, Rix P, Merkurjev D, Zaretsky J, Kornblum H, Ribas H, Herschman H, Whitelegge J, Faull K, Donahue T, Czernin J, and Radu C (2017) ATR inhibition facilitates targeting of leukemia dependence on convergent nucleotide biosynthetic pathways, Nature Communications, Aug 14;8(1):24PMID: 28808226 PMC5556071
98. Senese S, Lo YC, Gholkar AA, Li CM, Huang Y, Mottahedeh J, Kornblum HI, Damoisaux R, Torres JZ (2017) Microtubins: a novel class of small synthetic microtubule targeting drugs that inhibit cancer cell proliferation, Oncotarget, Oct 19;8(61):104007-104021. doi: 10.18632/oncotarget.21945. eCollection 2017 Nov 28. PMC5732783
99. Mai WX, Gosa L, Daniels VW, Ta L, Tsang JE, Higgins B, Gilmore WB, Bayley NA, Harati MD, Lee JT, Yong WH, Kornblum HI, Bensinger SJ, Mischel PS, Rao PN, Clark PM, Cloughesy TF, Letai A, and Nathanson DA (2017) Cytoplasmic p53 couples oncogene-driven glucose metabolism to apoptosis and is a therapeutic target in glioblastoma, Nature Medicine, Nov;23(11):1342-1351. Oct 9. PMID29035366. PMCID: PMC5732783
100. Laks DR, Oses-Prieto JA, Alvarado AG, Nakashima J, Chand S, Azzam DB, Gholkar AA, Sperry J, Ludwig K, Condro MC, Nazarian S, Cardenas A, Shih MYS, Damoiseaux R, France B, Orozco N,Visnyei K, Crisman TJ, Gao F, Torres JZ, Coppola G, Burlingame AL, Kornblum HI. (2018) Molecular Cascade Modulates MAP1B and Confers Resistance to mTOR Inhibition in Human Glioblastoma. Neuro-Oncology May 18;20(6):764-775. doi: 10.1093/neuonc/nox215.
101. Garrett M*, Sperry J*, Braas D, Yan W, Le T, Mottahedeh J, Ludwig K, Eskin A, Qin Y, Levy R, Breunig JJ, Pajonk F, Graeber TG, Radu CG, Christofk H, Prins RM, Lai A, Liau LM, Coppola, G and Kornblum HI (2018) Metabolic characterization of isocitrate dehydrogenase (IDH) mutant and IDH wildtype gliomaspheres uncovers cell type-specifc vulnerabilities, Cancer & Metabolism, 6:4 https://doi.org/10.1186/s40170-018-0177-4 PMCID: PMC5905129
102. Li T, Cox CD, Ozer B, Nguyen NT, Nguyen HN, Lai TJ, Li S, Liu F, Kornblum HI, Liau LM, Nghiemphu PL, Cloughesy TF, Lai A (2018) D-2-Hydroxyglutarate is necessary and sufficient for isocitrate dehydrogenase 1 mutant-induced MIR148A promoter methylation, Mol. Cancer Res, March 15, Epub ahead of print, PMID: 29545476 PMCID: PMC5984679
103. Alban TJ, Alvarado AG, Sorensen MD, Bayik D, Volovetz J, Serbinowski E, Mulkearns-Hubert EE, Sinyuk M, Hale JS, Onzi GR, McGraw M, Huang P, Grabowski MM, Wathen CA, Ahluwalia MS , Radivoyevitch T, Kornblum HI, Kristensen BW, Vogelbaum MA, Lathia JD (2018) Global immune fingerprinting in glioblastoma patient peripheral blood reveals immune-suppression signatures associated with prognosis, JCI Insight. 2018 Nov 2;3(21). PMC6238746
104. Chen AS, Wardwell-Ozgo J, Shah NN, Wright D, Appin CL, Vigneswaran K, Brat DJ, Kornblum HI, Read RD (2019) Drak/STK17A drives neoplastic glial proliferation through modulation of MRLC signaling, Cancer Res. 2019 Mar 15;79(6):1085-1097. doi: 10.1158/0008-5472.CAN-18-0482. Epub 2018 Dec 10. PMID: 30530503
105. Liu F, Cox CD, Chowdhury R, Dovek L, Nguyen H, Li T, Li S, Ozer B, Chou A, Nguyen N, Wei B, Antonios J, Soto H, Kornblum HI, Liau L, Prins R, Nghiemphu PL, Yong W, Cloughesy T, Lai A. (2019) SPINT2 is hypermethylated in both IDH1 mutated and wild-type glioblastomas, and exerts tumor suppression via reduction of c-Met activation. J Neurooncol. May;142(3):423-434. doi: 10.1007/s11060-019-03126-x. Epub 2019
106. Bi J, Ichu TA, Zanca C, Yang H, Zhang W, Gu Y, Chowdhry S, Reed A, Ikegami S, Turner KM, Zhang W, Villa GR, Wu S, Quehenberger O, Yong WH, Kornblum HI, Rich JN, Cloughesy TF, Cavenee WK, Furnari FB, Cravatt BF, Mischel PS (2019) Oncogene Amplification in Growth Factor Signaling Pathways Renders Cancers Dependent on Membrane Lipid Remodeling. Cell Metab. Sep 3; 30(3): 525–538.e8. Published online 2019 Jul 11. doi: 10.1016/j.cmet.2019.06.014 PMCID: PMC6742496
107. Peereboom DM, Alban TJ, Grabowski MM, Alvarado AG, Otvos B, Bayik D, Roversi G, McGraw M, Huang P, Mohammadi AM, Kornblum HI, Radivoyevitch T, Ahluwalia MS, Vogelbaum MA, Lathia JD (2019) Metronomic capecitabine as an immune modulator in glioblastoma patients reduces myeloid derived suppressor cells, JCI Insight, Nov 14;4(22). pii: 130748. doi: 10.1172/jci.insight.130748
108. Yamashita D, Bernstock JD, Elsayed G, Sadahiro H, Mohyeldin A, Chagoya G, Ilyas A, Mooney J, Estevez-Ordonez E, Yamaguchi S, Flanary V, Hackney JR, Bhat KP, Kornblum HI, Zamboni N, Kim SH, Chiocca EA, Nakano I (2020) Targeting glioma-initiating cells via tyrosine metabolic pathway, J. Neurosurg. Feb 14:1-12. doi: 10.3171/2019.11.
109. Saki M, Bhat K, Sodhi SS, Nguyen NT, Kornblum HI, Pajonk F (2020) Effects of Brain Irradiation in Immune-Competent and Immune-Compromised Mouse Models Radiat Res. Feb;193(2):186-194 PMID:31774721. PMCID: PMC7135898
110. Bhat K, Saki M, Vlashi E, Cheng F, Duhachek-Muggy S, Alli C, Yu G, Medina P, He L, Damoiseaux R, Pellegrini M, Zemke NR, Nghiemphu PL, Cloughesy TF, Liau LM, Kornblum HI, Pajonk F. (2020) The dopamine receptor antagonist trifluoperazine prevents phenotype conversion and improves survival in mouse models of glioblastoma. Proc Natl Acad Sci U S A (PNAS). 2020 May 19;117(20):11085-11096. doi: 10.1073/pnas.1920154117. Epub 2020 May 1. PMCID: PMC7245100
111. Bhat K, Medina P, He L, Zhang L, Saki M, Ioannidis A, Nguyen NT, Sodhi SS, Sung D, Magyar CE, Liau LM, Kornblum HI, Pajonk F (2020) 1-[(4-Nitrophenyl)sulfonyl]-4-phenylpiperazine Treatment After Brain Irradiation Preserves Cognitive Function in Mice. Neuro Oncol. 2020 Apr 15:noaa095. doi: 10.1093/neuonc/noaa095. Online ahead of print. PMID: 32291451
112. Garrett MC, O’Shea TM, Wollenberg AL, Bernstein AM, Hung D, Staarman B, Soto H, Demming T, Sofroniew MV, Kornblum HI (2020) Injectable diblock copolypeptide Hydrogel Provides a Platform to Maintain High Local Concentrations of Taxol and Local Tumor Control, PLoS One. 2020 Jul 24;15(7):e0219632. doi: 10.1371/journal.pone.0219632. eCollection 2020. PMID: 32706829 PMCID: PMC7380637.
113. Patel KS, Yao J, Raymond C, Yong W, Everson R, Liau LM, Nathanson D, Kornblum H, Wang C, Oughourlian T, Lai A, Nghiemphu P, Pope W, Cloughsey T, Ellingson B. (2020) Decorin expression is associated with predictive diffusion MR phenotypes of anti-VEGF efficacy in glioblastoma. Sci Rep. 2020 Sep 9;10(1):14819. doi: 10.1038/s41598-020-71799-w. PMCID: 7481206
114. Sperry J, Le Belle JE, Condro MC, Guo L, Braas D, Vanderveer-Harris N, Kim KKO, Pope WB, Divakaruni AS, Lai A, Christofk H, Kornblum HI (2020) Metabolism of fatty acids and ketone bodies for glioblastoma growth: Implications for Ketogenic Diet Therapy iScience 23 (2020) 101453. PMCID 7471621.
115. Kaneko N, Satta S, Komuro Y, Muthukrishnan SD, Kakarla V, Guo L, An J, Kornblum HI, Liebeskind DS, Hsiai T, Hinman JD, (2021) Flow-mediated Susceptibility and Molecular Response of Cerebral Endothelia to Sars-CoV-2 Infection, Stroke. Jan;52(1):260-270.doi: 10.1161/STROKEAHA.120.032764
116. Lei K, Gu X, Alvarado AG, Du Y, Luo S, Ahn EH, Kang SS, Ji B, Liu X, Mao H, Fu H, Kornblum HI, Jin L, Li H, Ye K. Discovery of a dual inhibitor of NQO1 and GSTP1 for treating glioblastoma J Hematol Oncol. 2020 Oct 21;13(1):141. doi: 10.1186/s13045-020-00979-y. PMID: 33087132. PMCID 7579906
117. Li C, Cho HJ, Yamashita D, Abdelrashid M, Chen Q, Bastola S, Chagoya G, Elsayed GA, Komarova S, Ozaki S, Ohtsuka Y, Kunieda T, Kornblum HI, Kondo T, Nam DH, Nakano I (2020). Tumor Edge-to-Core Transition Promotes Malignancy in Primary-to-Recurrent Glioblastoma Progression in a PLAGL1/CD109-mediated mechanism, , Neurooncol Adv. 2020 Nov 27;2(1):vdaa163. doi: 10.1093/noajnl/vdaa163. eCollection 2020 Jan-Dec., PMCID: 7764499
118. Bhat K, Saki M, Cheng F, He L, Zhang L, Ionnidis A, Nathanson D, Tsang J, Bensinger SJ, Nghiemphu PL, Cloughesy TF, Liau LM, Kornbum HI, Pajonk F (2021) Dopamine Receptor Antagonists, Radiation, and Cholesterol Biosynthesis in Mouse Models of Glioblastoma, J Natl Cancer Inst., 2021 Feb 9:djab018. doi: 10.1093/jnci/djab018. Online ahead of print. PMID: 33556960.
119. Ziegler M, Russell BE, Geisel G, D’Amore A, Sahin M, Kornblum HI, Ebrahimi-Fakhari D (2021) Blended Phenotype of Silver-Russell Syndrome and SPG50 Caused by maternal isodisomy of Chromosome 7, Neurol Genet. 2020 Dec 29;7(1):e544. doi: 10.1212/NXG.0000000000000544. eCollection 2021 PMC7862086
120. Li J, Pan L, Pembroke WG, Rexach JE, Godoy MI, Condro MC, Alvarado AG, Harteni M, Chen YW, Stiles L, Chen AY, Wanner IB,Yang X, Goldman SA, Geschwind DH, Kornblum HI, Zhang Y (2021) Conservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes, Nature Comm. 12:3958 | https://doi.org/10.1038/s41467-021-24232-3 |www.nature.com/naturecommunications PMID: 34172753 PMC8233314
121. He L, Bhat K, Ioannidis A, Zhang L, Nguyen NT, Allen JE, Nghiemphu PL, Cloughesy TF, Liau LM, Kornblum HI, Pajonk F (2021) Effects of the DRD2/3 antagonist ONC201 and radiation in glioblastoma. Nat Commun. 2021 Jun 25;12(1):3958. doi: 10.1038/s41467-021-24232-3. PMID: 34172753
122. Alban TJ, Bayik D, Alvarado AG, Kornblum HI, Lathia JD (2021) High-Dimensional Analysis of Circulating and Tissue-Derived Myeloid-Derived Suppressor Cells from Patients with Glioblastoma. Methods Mol Biol. 2021;2236:157-175. doi: 10.1007/978-1-0716-1060-2_13. PMID: 33237547.
123. Bi J, Khan A, Tang J, SiWu S, Zhang W, Gimple RC, Koga T, Armando AM, Miki S, Yang H, Prager B, Curtis EJ, Wainwright DA, Furnari FB, Rich JN, Cloughesy TF, Quehenberger O, Kornblum HI, Rzhetsky A, Cravatt BF, Mischel PS (2021) Targeting Glioblastoma Signaling and Metabolism with A Re-Purposed Brain-Penetrant Drug, Cell Rep. 2021 Nov 2;37(5):109957. doi: 10.1016/j.celrep.2021.109957. PMID: 34731610.
124. Larianova TD, Bastola S, Aksinina TE, Anufrieva KS, Wang J, Shender VO, Andreev DE, Kovalenko TF, Arapidi GP, Shnaider PV, Kazakova AN, Latyshev YA, Tatarskiy VV, Shtil AA, Moreau P, Giraud F, Li C, Wang Y, Rubtsova MP, Dontsova OA, Ellingson BM, Shakhparonov MI, Kornblum HI, Nakano I, Pavlyukov MS (2022) Alternative RNA splicing modulates the composition of ribosomes and determines spatial phenotype of glioblastoma cells, Nature Cell Biology, in Press.
125. Shi DD, Savani MR, Levitt MM, Wang AC, Endress JE, Bird CE, Buehler J, Stopka SA, Regan MS, Lin YF, Puliyappadamba VT, Gao W, Khanal J, Evans L, Lee JH Guo L, Xiao Y, Xu M, Huang B, Jennings RB, Bonal DM, Martin-Sandoval MS, Dang T, Gattie LC, Cameron AB, Lee S, Asara JM, Kornblum HI, Mak TW, Looper RE, Nguyen QD, Signoretti S, Gradl S, Sutter A, Jeffers M, Janzer A, Leherman MA, Zacharias LG, Mattews TP, Losman JA, Richardson TE, Cahill DP, DeBerardinis RJ, Ligon KL, Xu L, Ly P, Agar NYR, Abdulla KG, Harris IS, Kaelin WG, McBrayer SK (2022) De Novo Primidine Synthesis is a Targetable Vulnerability in IDH Mutant Glioma, Cancer Cell, 2022 Aug 12;S1535-6108(22)00324-5.mdoi: 10.1016/j.ccell.2022.07.011.
126. Alvarado AG Tessema K, Muthukrishnan KT, Sober M, Kawaguchi R, Bhaduri A, Laks DR, Swarup V,Nathanson DA, Goldman SA, Kornblum HI (2022). Pathway-based approach reveals differential sensitivity of glioblastoma to E2F1 inhibition, Cancer Research Communications, https://doi.org/10.1158/2767-9764.CRC-22-0003.
127. Muthukrishnan SD, Kawaguchi R, Nair P, Prasad R, Qin Y, Johnson M, Vanderveer-Harris N, Pham A, Wang Q, Condro MC, Alvarado AG, Gau R, Castro MG, Lowenstein PR, Deb A, Hinman JD, Pajonk F, Burns TC, Goldman SA, Geschwind D, Kornblum HI (2022). P300-mediated adaptive conversion of glioma stem cells to vascular-like cells in response to therapeutic stress promotes tumor recurrence. Nature Communications, in Press.